Endocrine Abstracts

Introduction: Accumulating evidence suggests a role for IGF1 in insulin resistance and cardiovascular disease. IGF1 enhances glucose uptake and nitric oxide (NO) production, via similar mechanisms to insulin. Previously we have reported a mouse model with global heterozygous knockout of the IGF1 receptor (IGF1RKO) that has enhanced insulin sensitivity and increased nitric oxide (NO) production in the vasculature.Methods: To investigate this further we us...

Background: Hyperthyroidism is associated with an increased risk of atherothrombosis and venous thrombotic events by mechanisms that are not fully understood. Previous work has shown that blood clot structure determines the susceptibility to thrombosis and therefore the aim of this study was to investigate the effects of hyperthyroidism on clot structure and fibrinolysis.Methods: Six patients with hyperthyroidism were included in a pilot longitudinal stu...

Hyperthyroidism is associated with increased thrombotic risk through mechanisms that are not fully understood. In contrast, a tendency to bleeding has been reported in hypothyroidism. Fibrin network structure has been shown to determine susceptibility to atherothrombosis and venous thrombotic events and therefore, this study investigates the effects of thyroid-dysfunction on clot structure and fibrinolysis using longitudinal interventional studies.Sevent...

Introduction: Polycystic ovary syndrome (PCOS) is associated with known cardiovascular risk factors, consequently predisposing to premature cardiovascular disease. Blood clot structure has been shown to predict predisposition to atherothrombosis and the aim of this study was to investigate the effects of rimonabant and metformin on clot structure/function in women with PCOS.Methods: Twenty women with PCOS were recruited in a randomised open labelled para...